Defining Zoledronate’s Duration of Action and Optimal Dosing Interval for an Effective Therapy
نویسنده
چکیده
Zoledronic acid (ZA) is a potent nitrogen-containing bisphosphonate with a long skeletal half-life that is administered annually by intravenous (IV) infusion. In the Horizon trial, ZA significantly reduced the risk of vertebral fracture by 70%, the risk of hip fracture by 40%, and the risk of nonvertebral fracture by 20% [1]. ZA also reduced the risk of clinical fracture by 35% and decreased mortality by 28% after hip fracture in the Recurrent Fracture Trial [2]. A combination of antifracture efficacy, low rate of adverse events, and infrequent dosing make it a desirable agent for the future.
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